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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are typically described as a focus on the practical aspects of design which include recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from different geographical regions. This kind of heterogeneity, which is essential for pragmatic trials to be valid and reduce bias in results, is also necessary. However, too much heterogeneity, can cause problems with the design of the trial.

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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They can also be a great method to determine the causality between an intervention and its outcomes. They should, however, not be used to replace explanatory studies.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study that includes the recruitment, design, and delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and 프라그마틱 정품확인방법 프라그마틱 슬롯 무료스핀 [mcbride-bachmann-4.blogbright.net] naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to keep in mind, however, that the majority were conducted in primary care settings.