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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from various geographical areas. This kind of heterogeneity, which is vital for pragmatic trials to be reliable and lessen the chance of bias is also essential. However excessive heterogeneity could cause issues with the design of the trial.
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Pragmatic trials aim to mimic real-life settings and 프라그마틱 불법 achieve maximum external validity. They are typically ordered by policymakers and practitioners in order to guide their decisions. They can also be used to determine the causal relationship between an intervention with its outcomes. They should, however, not, be used to replace explanation studies.
The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials that inform policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study that includes the recruitment, design, and delivery of the intervention and its follow-up.
There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, as shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority were conducted in primary-care settings.