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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically characterized by a focus on the practical aspects of the research design, like the recruitment process and consent, adherence, and the use of commonly available equipment.

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A practical trial that employs different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for 프라그마틱 무료체험 메타 a pragmatic trial to be reliable and lessen the chance of bias, is also necessary. However excessive heterogeneity could result in issues with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can be used to determine the causality of an intervention and its results. However, they shouldn't be used in lieu for explanatory trials.

The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool sought to define the features of a practical trial, including recruitment, design and delivery of the intervention, as well as follow-up.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note that the majority of studies were conducted in primary care settings.