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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are typically focused on the practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of standard equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from different geographical regions. This type of heterogeneity which is essential for pragmatic trials to be reliable and lessen the chance of bias is also essential. However, too much heterogeneity can result in issues with the design of the trial.
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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically requested by practitioners and policymakers in order to inform their decisions. They can be used to determine the causal relationship between an intervention and its results. However, 프라그마틱 무료체험 they should not be used as a substitute for the use of explanation trials.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should be used to replace explanation tests or if they should be an addition to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also proposed a framework called PRECIS for 프라그마틱 pragmatic trials.2 This tool tried to define the elements of a practical study, including recruitment, design, delivery of the intervention and follow-up.
There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatics. It is important to note that the majority were conducted in primary-care settings.