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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are typically characterized by a focus on the practical aspects of the research design, like the recruitment and consent process as well as adherence to the use of standard equipment.

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A pragmatic trial that uses various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for a pragmatic trial to be valid and lessen the chance of bias, 프라그마틱 게임 (Https://www.google.co.uz/url?q=Https://gravgaard-mack-2.Hubstack.net/the-complete-guide-to-pragmatic) is also necessary. However too much heterogeneity could cause problems with the design of the trial.

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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually commissioned by practitioners and policy makers to guide their decision-making. They are also a good method of determining the causal relationship between the intervention and its effects. However, they should not, be used to replace the need for explanation studies.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials, which guide the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study which includes the recruitment, design, and delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) resulted in 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority of studies were conducted in primary care settings.