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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are often characterized as focusing on practical aspects of design, including recruitment and consent, adherence and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from various geographical areas. This type of heterogeneity, which is essential for pragmatic trials to be valid and lessen the chance of bias, is also necessary. A high degree of heterogeneity, however, can cause problems with the trial design.

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Legality

Pragmatic Play has earned a reputation for providing high-quality games and a superior user experience. Its software is designed to work with mobile devices and supports different languages. It has established itself as one of the leading casino gaming platforms despite its relatively young age. Its latest releases include Wolves which is a five-reel video slot with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to determine the causality of an intervention with its outcomes. They should not, however be used to replace explanatory studies.

The pragmatism concept is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study, including recruitment, design, implementation of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary-care settings.