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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically described by their focus on practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be valid and also helps reduce the chance of bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.

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Pragmatic trials seek to replicate real-life settings and 프라그마틱 무료 슬롯버프 공식홈페이지 (Https://skanderborg.Maulbiler.dk/) achieve maximum external validity. They are usually commissioned by practitioners and policy makers to inform their decision making. They are also a good way to identify the cause-effect relationship between an intervention and its results. However, they should not be used to replace explanation studies.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a practical trial that include the recruitment process, the design and implementation of the intervention, as well as follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, 프라그마틱 무료 슬롯 which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.